Fig. 5
From: Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice
Analysis of spine density in DG neurons of wild type and daDREAM mice. a Sholl analysis showing equal dendritic length in wild type (wt) and daDREAM (tg) mice at all distances from soma. b The number of the intersections in granular neurons is similar between genotypes at all distances from soma. A significant increase in spine density in tg neurons was observed by Sholl analysis (c) (wt, n = 7; tg, n = 7, Two-way ANOVA, P < 0.0001 for genotype) and measured per branch order (d) (wt, n = 7; tg, n = 7, Two-way ANOVA, P < 0.001 for genotype). For c, sigmoidal curve fitting was used (P < 0.0001). For d, centered second order polynomial curve fitting was used (P < 0.0005). e Total number of spines in the basal dendritic tree showing statistically significant higher number in daDREAM neurons (n = 8 mice in each group; Two-way ANOVA, P < 0.001). Centered third order polynomial curve fitting was used (P < 0.0052)