Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice

Table 1 DREAM is a multifunctional regulatory protein

Modified function	Regulated by	Molecular mechanism	References
Kv4 channel gating & membrane localization	Calcium Lipids Phosphorylation by GRK2	Protein-protein interaction	An et al., 2000 [10] Holmqvist et al., 2001 [70] Ruiz-Gomez et al., 2007 [71]
Ca²⁺ release from the ER	Not known	Protein-protein interaction	Lilliehook et al., 2002 [72]
Voltage-gated Ca²⁺ channel expression & gating	Calcium	Transcriptional regulation	Ronkainen et al., 2011 [73] Naranjo & Mellstrom, 2012 [24]
Voltage-gated Ca²⁺ channel expression & gating	Calcium	Protein-protein interaction	Thomsen et al., 2009 [74] Anderson et al., 2010 [75]
Ca²⁺ influx through NMDA receptors	Calcium	Protein-protein interaction	Wu et al., 2010 [14] Zhang et al., 2010 [15]
GABAergic inhibition	Calcium	Transcriptional regulation	Mellstrom et al., 2014 [16]
Chronic pain desensitization	Calcium & BDNF	Transcriptional regulation	Rivera-Arconada et al., 2010 [30]
ATF6 processing	Calcium	Protein-protein interaction	Naranjo et al., 2016 [25]
Pain perception	Calcium	Transcriptional regulation	Carrion et al., 1999 [9] Cheng et al., 2002 [26]
Pain perception	Calcium	Protein-protein interaction	Hu et al., 2006 [76]

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