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Table 1 DREAM is a multifunctional regulatory protein

From: Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice

Modified function Regulated by Molecular mechanism References
Kv4 channel gating & membrane localization Calcium
Lipids
Phosphorylation by GRK2
Protein-protein interaction An et al., 2000 [10]
Holmqvist et al., 2001 [70]
Ruiz-Gomez et al., 2007 [71]
Ca2+ release from the ER Not known Protein-protein interaction Lilliehook et al., 2002 [72]
Voltage-gated Ca2+ channel expression & gating Calcium Transcriptional regulation Ronkainen et al., 2011 [73]
Naranjo & Mellstrom, 2012 [24]
Protein-protein interaction Thomsen et al., 2009 [74]
Anderson et al., 2010 [75]
Ca2+ influx through NMDA receptors Calcium Protein-protein interaction Wu et al., 2010 [14]
Zhang et al., 2010 [15]
GABAergic inhibition Calcium Transcriptional regulation Mellstrom et al., 2014 [16]
Chronic pain desensitization Calcium & BDNF Transcriptional regulation Rivera-Arconada et al., 2010 [30]
ATF6 processing Calcium Protein-protein
interaction
Naranjo et al., 2016 [25]
Pain perception Calcium Transcriptional regulation Carrion et al., 1999 [9]
Cheng et al., 2002 [26]
Protein-protein interaction Hu et al., 2006 [76]