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Fig. 3 | Molecular Brain

Fig. 3

From: Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease

Fig. 3

Degradation of MBP in the temporal lobe of AD + CVD subjects. Degradation ratio of MBP was calculated based on the peptide intensity areas in each group showing exact match with previous reported MBP degradation byproducts by the effect of cathepsin D (see detailed explanation of that method in the material and methods section). All ratios were normalized to age-matched controls (ratio 1 = normal degradation). a Degradation ratio of the MBP byproduct TQ#DENPVVHF in women and men with dementia. As shown, higher ratio of Gln deamidation (>2.0) in the MBP byproduct TQ#DENPVVHF was associated with lower degradation ratio (<0.5) of the protein in AD + CVD women. b Degradation ratio of the MBP byproduct YLATASTMDHAR# in women and men with dementia. MBP degradation ratio of this byproduct in AD + CVD women (≈1) was not affected by the increased level of citrullination (ratio ≈ 2.5)

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