Age-matched control subjects | |||||||
Gender | Age | PMa delay | Cognitive assessment | Cog. exam. | Braak | CERAD | Neuropathology |
M | 72 | 17 | Normal control | Retrospective Interview | 1 | Sparse | Mild AD-like pathology |
M | 75 | 20 | Normal control | Retrospective Interview | 0 | None | Scattered microinfarcts (in right hemisphere: hippocampal CA2/3, putamen, caudate, external medullary lamina) and SVD: Foci of arteriosclerosis mainly in white matter |
F | 68 | 75 | Normal control | Retrospective Interview | 1 | Sparse | Mild cerebral amyloid angiopathy. A right frontal microinfarct and small lacunar infarct in the left putamen. Infarcts in both cortex and basal ganglia |
F | 78 | 23 | Normal control | Retrospective Interview | 2 | Sparse | Mild AD-like pathology |
F | 82 | 26 | Normal control | Retrospective Interview | 0 | N.A. | No detected AD or CVD pathology |
F | 87 | 14 | Normal control | Retrospective Interview | N.A. | N.A. | Low mean density of neocortical tangles = 2.5 per mm2. |
F | 99 | 19 | Normal control | Retrospective Interview | N.A. | None | No detected AD or CVD pathology |
F | 86 | 40 | Normal control | Retrospective Interview | 1 | N.A. | No detected AD or CVD pathology |
F | 75 | 31 | Normal control | Retrospective Interview | N.A. | N.A. | No detected AD or CVD pathology |
F | 81 | 51 | Normal control | Retrospective Interview | N.A. | N.A. | No detected AD or CVD pathology |
Mean | 80.3 ± 8.9 | 31.6 ± 19 | |||||
AD + CVD subjects | |||||||
Gender | Age | PMa delay | Cognitive assessment | Cog. exam. | Braak | CERAD | Neuropathology |
M | 83 | 71 | 1 y. cog imp. | M.M.S.E = 18 | 4 | Moderate | Mixed pathology - AD and SVD (predominantly microinfarcts in frontal lobe & perivascular lacunae in basal ganglia). Cavernous hemangioma in right ventrolateral posterior centrum semiovale. Loss of myelin in brain capsules. |
M | 72 | 29 | 7 y. cog imp. | M.M.S.E = 20 | 4 | Frequent | Mixed AD and CVD. Microinfarcts in putamen. Loss of myelin in internal capsule |
M | 84 | 42 | 8 y. cog imp. | M.M.S.E = 13 | 5 | N.A. | Mixed pathology AD with vascular dementia and severe cerebral amyloid angiopathy. |
M | 82 | 38 | 1 y. dementia | M.M.S.E = 16 | 6 | N.A. | Mixed pathology AD with old infarcts in the temporal cortex right hemisphere. CVD affecting parietal and occipital lobes. Microinfarcts in caudate and putamen. Focal loss of myelin in brain capsules. |
M | 64 | 24 | 1 y. dementia | M.M.S.E = 20 | N.A. | N.A. | Mixed pathology AD + CVD affecting middle temporal gyrus, parietal and occipital lobes. Myelin affectation in brain capsules. |
Mean | 77 ± 8.7 | 41 ± 18 | |||||
F | 93 | 18 | 2 y. dementia | S.I.B = 75/100 | 5 | Frequent | Mixed pathology AD + CVD affecting parietal and temporal lobes. Myelin affectation in brain capsules. |
F | 89 | 72 | 4 y. cog. imp. | M.M.S.E = 16 | 4 | N.A. | Mixed pathology AD + CVD affecting temporal lobes and brainstem. Severe myelin affectation in medial and internal temporal gyrus. |
F | 89 | 32 | 3 y. cog. imp. | M.T.S = 5/37 | 5 | N.A. | Mixed pathology AD + CVD. Severe changes in hippocampus. Neurofibrillary tangles in raphe nucleus. |
F | 92 | 12 | 5 y. dementia | M.M.S.E = 20 | 5 | N.A. | Mixed pathology AD + CVD affecting middle temporal gyrus and parietal/occipital lobes. Severe myelin affectation in temporal cortex. |
F | 86 | 99 | 2 y. dementia | M.M.S.E = 20 | 6 | N.A. | Mixed pathology AD + CVD. Moderate temporoparietal infarcts. |
Mean | 89.8 ± 2.8 | 46.6 ± 37.5 |