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Table 1 Demographic and clinical data of dementia subjects and age-matched control subjects. 1. Post-mortem delay

From: Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease

Age-matched control subjects

Gender

Age

PMa delay

Cognitive assessment

Cog. exam.

Braak

CERAD

Neuropathology

M

72

17

Normal control

Retrospective Interview

1

Sparse

Mild AD-like pathology

M

75

20

Normal control

Retrospective Interview

0

None

Scattered microinfarcts (in right hemisphere: hippocampal CA2/3, putamen, caudate, external medullary lamina) and SVD: Foci of arteriosclerosis mainly in white matter

F

68

75

Normal control

Retrospective Interview

1

Sparse

Mild cerebral amyloid angiopathy. A right frontal microinfarct and small lacunar infarct in the left putamen. Infarcts in both cortex and basal ganglia

F

78

23

Normal control

Retrospective Interview

2

Sparse

Mild AD-like pathology

F

82

26

Normal control

Retrospective Interview

0

N.A.

No detected AD or CVD pathology

F

87

14

Normal control

Retrospective Interview

N.A.

N.A.

Low mean density of neocortical tangles = 2.5 per mm2.

F

99

19

Normal control

Retrospective Interview

N.A.

None

No detected AD or CVD pathology

F

86

40

Normal control

Retrospective Interview

1

N.A.

No detected AD or CVD pathology

F

75

31

Normal control

Retrospective Interview

N.A.

N.A.

No detected AD or CVD pathology

F

81

51

Normal control

Retrospective Interview

N.A.

N.A.

No detected AD or CVD pathology

Mean

80.3 ± 8.9

31.6 ± 19

     

AD + CVD subjects

Gender

Age

PMa delay

Cognitive assessment

Cog. exam.

Braak

CERAD

Neuropathology

M

83

71

1 y. cog imp.

M.M.S.E = 18

4

Moderate

Mixed pathology - AD and SVD (predominantly microinfarcts in frontal lobe & perivascular lacunae in basal ganglia). Cavernous hemangioma in right ventrolateral posterior centrum semiovale. Loss of myelin in brain capsules.

M

72

29

7 y. cog imp.

M.M.S.E = 20

4

Frequent

Mixed AD and CVD. Microinfarcts in putamen. Loss of myelin in internal capsule

M

84

42

8 y. cog imp.

M.M.S.E = 13

5

N.A.

Mixed pathology AD with vascular dementia and severe cerebral amyloid angiopathy.

M

82

38

1 y. dementia

M.M.S.E = 16

6

N.A.

Mixed pathology AD with old infarcts in the temporal cortex right hemisphere. CVD affecting parietal and occipital lobes. Microinfarcts in caudate and putamen. Focal loss of myelin in brain capsules.

M

64

24

1 y. dementia

M.M.S.E = 20

N.A.

N.A.

Mixed pathology AD + CVD affecting middle temporal gyrus, parietal and occipital lobes. Myelin affectation in brain capsules.

Mean

77 ± 8.7

41 ± 18

     

F

93

18

2 y. dementia

S.I.B = 75/100

5

Frequent

Mixed pathology AD + CVD affecting parietal and temporal lobes. Myelin affectation in brain capsules.

F

89

72

4 y. cog. imp.

M.M.S.E = 16

4

N.A.

Mixed pathology AD + CVD affecting temporal lobes and brainstem. Severe myelin affectation in medial and internal temporal gyrus.

F

89

32

3 y. cog. imp.

M.T.S = 5/37

5

N.A.

Mixed pathology AD + CVD. Severe changes in hippocampus. Neurofibrillary tangles in raphe nucleus.

F

92

12

5 y. dementia

M.M.S.E = 20

5

N.A.

Mixed pathology AD + CVD affecting middle temporal gyrus and parietal/occipital lobes. Severe myelin affectation in temporal cortex.

F

86

99

2 y. dementia

M.M.S.E = 20

6

N.A.

Mixed pathology AD + CVD. Moderate temporoparietal infarcts.

Mean

89.8 ± 2.8

46.6 ± 37.5

     
  1. aPost-mortem delay