Fig. 3
From: Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
Potential pathogenesis of FBXO7 and Parkin mutations induced neuron degeneration in PD. FBXO7 mutations can lead to deleterious FBXO7 protein aggregation, inhibition of mitophagy process and impairment of FBXO7-linked UPS functions. Mutant FBXO7 proteins can form stress dependent toxic protein aggregates in mitochondria. The impaired mitophagy will also impair mitochondria functions. Besides, the impairment of FBXO7-linked UPS function may lead to accumulation of some toxic FBXO7 targets. All these alterations may converge and contribute to FBXO7 mutations induced neuron degeneration in PARK15. However Parkin mutations induced mitophagy impairment and accumulation of toxic Parkin targets may contribute to neuron degeneration in PARK2