Fig. 10
From: Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
Iron Modulates NMDA-R function via Src and PKC pathway which then mediates neuronal excitability. NMDA-mediated activation of Dexras1 modulates iron release from intracellular source, lysosome via iron transporter, DMT1 and this consequently suppresses synaptic NMDA activity by suppressing PKC/Src pathway. Therefore, Dexras1-mediated iron modulation in neurons can act in a feedback manner to modulate NMDA function and thus may exert homeostatic control of excitability