Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells

Fig. 6

Cooperative effects of ethanol and peroxide challenges on apoptosis and lysosomal/mitochondrial distribution. At day 7 after exposure to ethanol for 24hr or 7d, iPS cells were exposed for 14hr to 5 or 10 μM H2O2 and immunostained with antibodies against Oct4 and Casp3 (a), or stained with Mitotracker and Lamp1 (b). Both single treatments with ethanol and H2O2 alter the normal patterns of the cell, but a remarkable enhancement of the effects observed following a single challenge is evident following a double challenge. Scale bars: 50 μm (a), 10 μm (b)

Back to article page