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Fig. 7 | Molecular Brain

Fig. 7

From: Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons

Fig. 7

Model of PAK1 roles in the pathogenesis of diseases. An oxidative stress might induce activation of a phosphatase for PAK1 or inhibit phosphorylation of PAK1 via other mechanisms. Consequently, the down-regulation of PAK1 activity decreases the phosphorylation of Bcl-2 and the dephosphorylated Bcl-2 proteins are to be more susceptible to an ubiquitin/proteasome-dependent degradation. Reduction of Bcl-2 level induces loss of cells, such as mesencephalic dopamine neurons, thereby inducing Parkinson’s disease (PD)

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