Skip to main content
Fig. 1 | Molecular Brain

Fig. 1

From: LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias

Fig. 1

LRRK2 phosphorylation at Ser-935 in parkinsonian and dyskinetic rats. a The ipsilateral striatum from non lesioned (control), fully lesioned parkinsonian (6-OHDA), non dyskinetic (Non Dys) rats or animals displaying a dyskinetic behaviour (Dys) were analyzed by WB to evaluate the levels of LRRK2 phosphorylation at Ser-935 site (P-935). b The graph illustrates LRRK2 phosphorylation normalized upon total LRRK2 (n = 6; One-way Anova: *p < 0.05 Non Dys versus 6-OHDA °p < 0.01 Non dys versus Dysk, #p < 0.05, Dys versus 6-OHDA). Data are expressed as mean ± SEM. c Rats were injected in the left striatum with LRRK2 IN-1 inhibitor or vehicle (control) and the total and phosphorylated LRRK2 levels were evaluated by WB. d IN-1 reduced LRRK2 phosphorylation in vivo (n = 6; **p < 0.01, unpaired two-tailed Student’s t-test). Graph reports LRRK2 phosphorylation level normalized on the total amount of LRRK2 protein. Data are expressed as mean ± SEM

Back to article page