Fig. 1
From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease
mRNA levels of APE1, OGG1, Polβ and PARP1 in blood compared to human brain tissue (mean ± 2 SEM), p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001. a Relative mRNA levels of APE1 in blood compared to levels in human brain tissue. b Relative mRNA levels of OGG1 in blood compared to levels in human brain tissue. c Relative mRNA levels of Polβ in blood compared to levels in human brain tissue. d Relative mRNA levels of PARP1 in blood compared to levels in human brain tissue. The box plots shows that mRNA levels of all enzymes are significantly higher (p <0.0001) in brain tissue compared to blood, both in healthy controls and AD patients. Abbreviations: AD = Alzheimer’s disease, SCI = patients with subjective cognitive impairment, MCI = patients with mild cognitive impairment, MCI/AD = patients with mild cognitive impairment due to AD pathology