Fig. 4

Relative mRNA levels of OGG1 and PARP1 in CSF biomarker groups (mean ± SEM) in Aβ-42 and T-tau and/or P-tau, Aβ-42, T-tau and/or P-tau, patients with normal CSF levels of Aβ-42 and tau and healthy controls (HC). p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001. a The box plot show that mRNA levels of OGG1 are significantly reduced in the groups: patients with normal CSF levels of Aβ-42 and tau (p <0.05), abnormal tau (p <0.05) and high Aβ-42 levels (p <0.05) compared to HC. b The box plot show that mRNA levels of PARP1 are significantly increased in the groups: patients with normal CSF levels of Aβ-42 and tau (p <0.0001), abnormal tau levels (p <0.01) and high Aβ-42 levels (p <0.01) and both tau and Aβ-42 (p <0.01) compared to HC