From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease
Overall interaction between diagnosis and brain region | Specific interactions between diagnosis and brain region | ||||
---|---|---|---|---|---|
Base excision repair enzyme | p-value | p-value | Brain region | Effect | p-value |
APE1 | 0.034 | - * | → | ||
Frontal cortex | 0.13 | 0.61 | |||
Cerebellum | 0.17 | 0.49 | |||
Hippocampus | 0.33 | 0.22 | |||
Entorhinal cortex | −0.62 | 0.016 * | |||
Polβ | 0.0026 | - * | → | ||
Frontal cortex | 0.40 | 0.85 | |||
Cerebellum | 9.93 | 4.6E-06 **** | |||
Hippocampus | 0.24 | 0.92 | |||
Entorhinal cortex | 1.12 | 0.63 | |||
PARP1 | 2.40 E-09 | - * | → | ||
Frontal cortex | 0.33 | 0.63 | |||
Cerebellum | −2.43 | 0.00042*** | |||
Hippocampus | 0.16 | 0.004 ** | |||
Entorhinal cortex | 2.71 | 0.00018*** | |||
OGG1 | 0.25 | 0.57 |