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Table 1 APE1, OGG1, Polβ and PARP1 mRNA levels in brain regions of AD patients and healthy controls

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Overall interaction between diagnosis and brain region

Specific interactions between diagnosis and brain region

Base excision repair enzyme

p-value

p-value

Brain region

Effect

p-value

APE1

0.034

- *

  
 

Frontal cortex

0.13

0.61

Cerebellum

0.17

0.49

Hippocampus

0.33

0.22

Entorhinal cortex

−0.62

0.016 *

Polβ

0.0026

- *

  
 

Frontal cortex

0.40

0.85

Cerebellum

9.93

4.6E-06 ****

Hippocampus

0.24

0.92

Entorhinal cortex

1.12

0.63

PARP1

2.40 E-09

- *

  
 

Frontal cortex

0.33

0.63

Cerebellum

−2.43

0.00042***

Hippocampus

0.16

0.004 **

Entorhinal cortex

2.71

0.00018***

OGG1

0.25

0.57

   
  1. The significance of the specific interaction effects of diagnosis and brain region are only tested if the overall interaction effect is significant, otherwise the significance of the main effect of diagnosis is tested directly. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001