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Table 1 APE1, OGG1, Polβ and PARP1 mRNA levels in brain regions of AD patients and healthy controls

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Overall interaction between diagnosis and brain region Specific interactions between diagnosis and brain region
Base excision repair enzyme p-value p-value Brain region Effect p-value
APE1 0.034 - *   
  Frontal cortex 0.13 0.61
Cerebellum 0.17 0.49
Hippocampus 0.33 0.22
Entorhinal cortex −0.62 0.016 *
Polβ 0.0026 - *   
  Frontal cortex 0.40 0.85
Cerebellum 9.93 4.6E-06 ****
Hippocampus 0.24 0.92
Entorhinal cortex 1.12 0.63
PARP1 2.40 E-09 - *   
  Frontal cortex 0.33 0.63
Cerebellum −2.43 0.00042***
Hippocampus 0.16 0.004 **
Entorhinal cortex 2.71 0.00018***
OGG1 0.25 0.57    
  1. The significance of the specific interaction effects of diagnosis and brain region are only tested if the overall interaction effect is significant, otherwise the significance of the main effect of diagnosis is tested directly. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001