Skip to main content

Table 2 Comparison of mRNA levels of APE1, OGG1, Polβ and PARP1 in different brain regions of AD patients (AD) and healthy controls (HC)

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Base excision
repair enzyme
Reference brain part Compared brain part AD
p-value
HC
p-value
APE1 Frontal cortex Cerebellum 0.88 0.2
Frontal cortex Hippocampus 0.23 0.8
Frontal cortex Entorhinal cortex 0.8 0.3
Cerebellum Hippocampus 0.27 0.58
Cerebellum Entorhinal cortex 0.68 0.77
Hippocampus Entorhinal cortex 0.18 0.68
OGG1 Frontal cortex Cerebellum 0.11 0.55
Frontal cortex Hippocampus 0.66 0.83
Frontal cortex Entorhinal cortex 0.6 0.67
Cerebellum Hippocampus 0.4 0.6
Cerebellum Entorhinal cortex 0.31 0.87
Hippocampus Entorhinal cortex 0.99 0.77
Polβ Frontal cortex Cerebellum 0.002 ** 0.005**
Frontal cortex Hippocampus 0.34 0.21
Frontal cortex Entorhinal cortex 0.23 0.54
Cerebellum Hippocampus 0.00005**** 0.01**
Cerebellum Entorhinal cortex 0.0002**** 0.005**
Hippocampus Entorhinal cortex 0.78 0.17
PARP1 Frontal cortex Cerebellum 0.77 0.64
Frontal cortex Hippocampus 0.96 0.44
Frontal cortex Entorhinal cortex 0.66 0.43
Cerebellum Hippocampus 0.84 0.38
Cerebellum Entorhinal cortex 0.47 0.37
Hippocampus Entorhinal cortex 0.67 0.92
  1. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001