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Table 2 Comparison of mRNA levels of APE1, OGG1, Polβ and PARP1 in different brain regions of AD patients (AD) and healthy controls (HC)

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Base excision

repair enzyme

Reference brain part

Compared brain part

AD

p-value

HC

p-value

APE1

Frontal cortex

Cerebellum

0.88

0.2

Frontal cortex

Hippocampus

0.23

0.8

Frontal cortex

Entorhinal cortex

0.8

0.3

Cerebellum

Hippocampus

0.27

0.58

Cerebellum

Entorhinal cortex

0.68

0.77

Hippocampus

Entorhinal cortex

0.18

0.68

OGG1

Frontal cortex

Cerebellum

0.11

0.55

Frontal cortex

Hippocampus

0.66

0.83

Frontal cortex

Entorhinal cortex

0.6

0.67

Cerebellum

Hippocampus

0.4

0.6

Cerebellum

Entorhinal cortex

0.31

0.87

Hippocampus

Entorhinal cortex

0.99

0.77

Polβ

Frontal cortex

Cerebellum

0.002 **

0.005**

Frontal cortex

Hippocampus

0.34

0.21

Frontal cortex

Entorhinal cortex

0.23

0.54

Cerebellum

Hippocampus

0.00005****

0.01**

Cerebellum

Entorhinal cortex

0.0002****

0.005**

Hippocampus

Entorhinal cortex

0.78

0.17

PARP1

Frontal cortex

Cerebellum

0.77

0.64

Frontal cortex

Hippocampus

0.96

0.44

Frontal cortex

Entorhinal cortex

0.66

0.43

Cerebellum

Hippocampus

0.84

0.38

Cerebellum

Entorhinal cortex

0.47

0.37

Hippocampus

Entorhinal cortex

0.67

0.92

  1. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001