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Table 3 Association of clinical diagnosis, CSF biomarkers and age with mRNA levels ofAPE1, OGG1, Polβ and PARP1 in blood

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Clinical determinant

Diagnosis

Base Excision Repair Enzyme

Association recorded

p-value

AD dementia

APE1

0.04

0.598

MCI/AD

−0.06

0.508

MCI

−0.06

0.425

SCI

0.05

0.570

AD dementia

OGG1

−0.13

0.0324 *

MCI/AD

−0.13

0.0410 *

MCI

−0.15

0.0083 **

SCI

−0.08

0.1941

AD dementia

Polβ

0.22

0.0395 *

MCI/AD

0.12

0.3165

MCI

0.03

0.7295

SCI

0.11

0.3235

AD dementia

PARP1

0.27

0.018 *

MCI/AD

0.46

0.00014 ***

MCI

0.33

0.00150 **

SCI

0.48

0.00007 ****

CSF biomarkers

No CSF pathology

APE1

−0.05

0.492

Tau pathology

0.09

0.320

Aβ pathology

−0.08

0.453

Tau and Aβ pathology

0.02

0.856

No CSF pathology

OGG1

−0.12

0.0164 *

Tau pathology

−0.17

0.0103 *

Aβ pathology

−0.14

0.0468 *

Tau and Aβ pathology

−0.09

0.1826

No CSF pathology

Polβ

0.02

0.8508

Tau pathology

0.25

0.0352 *

Aβ pathology

0.14

0.2794

Tau and Aβ pathology

0.19

0.1180

No CSF pathology

PARP1

0.43

0.00002 ****

Tau pathology

0.40

0.0013 **

Aβ pathology

0.38

0.0053 **

Tau and Aβ pathology

0.32

0.0089 **

Age

Change over time: average effect per year

APE1

−0.004

0.14

OGG1

−0.0006

0.768

PARP1

−0.009

0.0196 *

Polβ

0.010

0.00599 **

  1. The parameters are compared to healthy controls. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001