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Table 3 Association of clinical diagnosis, CSF biomarkers and age with mRNA levels ofAPE1, OGG1, Polβ and PARP1 in blood

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Clinical determinant
Diagnosis
Base Excision Repair Enzyme Association recorded p-value
AD dementia APE1 0.04 0.598
MCI/AD −0.06 0.508
MCI −0.06 0.425
SCI 0.05 0.570
AD dementia OGG1 −0.13 0.0324 *
MCI/AD −0.13 0.0410 *
MCI −0.15 0.0083 **
SCI −0.08 0.1941
AD dementia Polβ 0.22 0.0395 *
MCI/AD 0.12 0.3165
MCI 0.03 0.7295
SCI 0.11 0.3235
AD dementia PARP1 0.27 0.018 *
MCI/AD 0.46 0.00014 ***
MCI 0.33 0.00150 **
SCI 0.48 0.00007 ****
CSF biomarkers
No CSF pathology APE1 −0.05 0.492
Tau pathology 0.09 0.320
Aβ pathology −0.08 0.453
Tau and Aβ pathology 0.02 0.856
No CSF pathology OGG1 −0.12 0.0164 *
Tau pathology −0.17 0.0103 *
Aβ pathology −0.14 0.0468 *
Tau and Aβ pathology −0.09 0.1826
No CSF pathology Polβ 0.02 0.8508
Tau pathology 0.25 0.0352 *
Aβ pathology 0.14 0.2794
Tau and Aβ pathology 0.19 0.1180
No CSF pathology PARP1 0.43 0.00002 ****
Tau pathology 0.40 0.0013 **
Aβ pathology 0.38 0.0053 **
Tau and Aβ pathology 0.32 0.0089 **
Age
Change over time: average effect per year APE1 −0.004 0.14
OGG1 −0.0006 0.768
PARP1 −0.009 0.0196 *
Polβ 0.010 0.00599 **
  1. The parameters are compared to healthy controls. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001