From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease
Gene | Brain parts | Mean NGE All brain parts | Mean NGE Blood | p-value |
---|---|---|---|---|
AD patients | ||||
APE1 | All brain parts | 1.73 | 1.06 | 2.69E-14 * |
OGG1 | All brain parts | 4.38 | 0.90 | <2.20e-16 * |
Polβ | All brain parts | 8.31 | 0.99 | 1.42E-10 * |
PARP1 | All brain parts | 3.45 | 1.14 | <2.20E-16 * |
APE1 | Frontal cortex | 1.55 | 1.06 | 1.0E-04 * |
Cerebellum | 2.19 | 1.06 | 7.76E-10 * | |
Hippocampus | 1.47 | 1.06 | 3.65E-05 * | |
Entorhinal cortex | 1.73 | 1.06 | 8.41E-08 * | |
OGG1 | Frontal cortex | 3.23 | 0.90 | 2.2E-11 * |
Cerebellum | 6.51 | 0.90 | 1.16E-11 * | |
Hippocampus | 3.91 | 0.90 | 5.44E-11 * | |
Entorhinal cortex | 3.93 | 0.90 | 9.62E-14 * | |
Polβ | Frontal cortex | 1.75 | 0.99 | 1.30E-04 * |
Cerebellum | 28.62 | 0.99 | 8.34E-16 * | |
Hippocampus | 1.58 | 0.99 | 8.40E-05 * | |
Entorhinal cortex | 2.37 | 0.99 | 1.30E-10 * | |
PARP1 | Frontal cortex | 2.17 | 1.14 | 4.67E-08 * |
Cerebellum | 2.86 | 1.14 | 3.12E-10 * | |
Hippocampus | 3.87 | 1.14 | 9.28E-11 * | |
Entorhinal cortex | 4.87 | 1.14 | 1.54E-11 * | |
Healthy controls | ||||
APE1 | All brain parts | 1.76 | 1.02 | 5.40E-05 * |
OGG1 | All brain parts | 3.27 | 1.02 | 1.20E-05 * |
Polβ | All brain parts | 6.20 | 0.78 | 2.47E-03 |
PARP1 | All brain parts | 2.85 | 0.87 | 2.10E-04 * |
APE1 | Frontal cortex | 1.41 | 1.02 | 2.10E-02 |
Cerebellum | 2.03 | 1.02 | 1.70E-04 * | |
Hippocampus | 1.16 | 1.02 | 1.40E-01 | |
Entorhinal cortex | 2.36 | 1.02 | 3.70E-02 | |
OGG1 | Frontal cortex | 2.69 | 1.02 | 3.70E-02 |
Cerebellum | 5.18 | 1.02 | 2.90E-04 * | |
Hippocampus | 1.85 | 1.02 | 5.70E-02 | |
Entorhinal cortex | 3.01 | 1.02 | 1.30E-01 | |
Polβ | Frontal cortex | 1.36 | 0.78 | 3.40E-02 |
Cerebellum | 18.69 | 0.78 | 4.70E-04 * | |
Hippocampus | 1.36 | 0.78 | 2.80E-03 | |
Entorhinal cortex | 1.20 | 0.78 | 2.30E-02 | |
PARP1 | Frontal cortex | 1.83 | 0.87 | 4.60E-02 |
Cerebellum | 5.31 | 0.87 | 1.30E-02 | |
Hippocampus | 1.81 | 0.87 | 5.50E-03 | |
Entorhinal cortex | 2.15 | 0.87 | 1.20E-02 |