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Table 4 mRNA levels of APE1, OGG1, Polβ and PARP1 in brain parts compared with blood

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Gene Brain parts Mean NGE
All brain parts
Mean NGE
Blood
p-value
AD patients
APE1 All brain parts 1.73 1.06 2.69E-14 *
OGG1 All brain parts 4.38 0.90 <2.20e-16 *
Polβ All brain parts 8.31 0.99 1.42E-10 *
PARP1 All brain parts 3.45 1.14 <2.20E-16 *
APE1 Frontal cortex 1.55 1.06 1.0E-04 *
Cerebellum 2.19 1.06 7.76E-10 *
Hippocampus 1.47 1.06 3.65E-05 *
Entorhinal cortex 1.73 1.06 8.41E-08 *
OGG1 Frontal cortex 3.23 0.90 2.2E-11 *
Cerebellum 6.51 0.90 1.16E-11 *
Hippocampus 3.91 0.90 5.44E-11 *
Entorhinal cortex 3.93 0.90 9.62E-14 *
Polβ Frontal cortex 1.75 0.99 1.30E-04 *
Cerebellum 28.62 0.99 8.34E-16 *
Hippocampus 1.58 0.99 8.40E-05 *
Entorhinal cortex 2.37 0.99 1.30E-10 *
PARP1 Frontal cortex 2.17 1.14 4.67E-08 *
Cerebellum 2.86 1.14 3.12E-10 *
Hippocampus 3.87 1.14 9.28E-11 *
Entorhinal cortex 4.87 1.14 1.54E-11 *
Healthy controls
APE1 All brain parts 1.76 1.02 5.40E-05 *
OGG1 All brain parts 3.27 1.02 1.20E-05 *
Polβ All brain parts 6.20 0.78 2.47E-03
PARP1 All brain parts 2.85 0.87 2.10E-04 *
APE1 Frontal cortex 1.41 1.02 2.10E-02
Cerebellum 2.03 1.02 1.70E-04 *
Hippocampus 1.16 1.02 1.40E-01
Entorhinal cortex 2.36 1.02 3.70E-02
OGG1 Frontal cortex 2.69 1.02 3.70E-02
Cerebellum 5.18 1.02 2.90E-04 *
Hippocampus 1.85 1.02 5.70E-02
Entorhinal cortex 3.01 1.02 1.30E-01
Polβ Frontal cortex 1.36 0.78 3.40E-02
Cerebellum 18.69 0.78 4.70E-04 *
Hippocampus 1.36 0.78 2.80E-03
Entorhinal cortex 1.20 0.78 2.30E-02
PARP1 Frontal cortex 1.83 0.87 4.60E-02
Cerebellum 5.31 0.87 1.30E-02
Hippocampus 1.81 0.87 5.50E-03
Entorhinal cortex 2.15 0.87 1.20E-02
  1. Abbreviations: NGE normalized mRNA levels, significant p-values: *