Skip to main content

Table 4 mRNA levels of APE1, OGG1, Polβ and PARP1 in brain parts compared with blood

From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

Gene

Brain parts

Mean NGE

All brain parts

Mean NGE

Blood

p-value

AD patients

APE1

All brain parts

1.73

1.06

2.69E-14 *

OGG1

All brain parts

4.38

0.90

<2.20e-16 *

Polβ

All brain parts

8.31

0.99

1.42E-10 *

PARP1

All brain parts

3.45

1.14

<2.20E-16 *

APE1

Frontal cortex

1.55

1.06

1.0E-04 *

Cerebellum

2.19

1.06

7.76E-10 *

Hippocampus

1.47

1.06

3.65E-05 *

Entorhinal cortex

1.73

1.06

8.41E-08 *

OGG1

Frontal cortex

3.23

0.90

2.2E-11 *

Cerebellum

6.51

0.90

1.16E-11 *

Hippocampus

3.91

0.90

5.44E-11 *

Entorhinal cortex

3.93

0.90

9.62E-14 *

Polβ

Frontal cortex

1.75

0.99

1.30E-04 *

Cerebellum

28.62

0.99

8.34E-16 *

Hippocampus

1.58

0.99

8.40E-05 *

Entorhinal cortex

2.37

0.99

1.30E-10 *

PARP1

Frontal cortex

2.17

1.14

4.67E-08 *

Cerebellum

2.86

1.14

3.12E-10 *

Hippocampus

3.87

1.14

9.28E-11 *

Entorhinal cortex

4.87

1.14

1.54E-11 *

Healthy controls

APE1

All brain parts

1.76

1.02

5.40E-05 *

OGG1

All brain parts

3.27

1.02

1.20E-05 *

Polβ

All brain parts

6.20

0.78

2.47E-03

PARP1

All brain parts

2.85

0.87

2.10E-04 *

APE1

Frontal cortex

1.41

1.02

2.10E-02

Cerebellum

2.03

1.02

1.70E-04 *

Hippocampus

1.16

1.02

1.40E-01

Entorhinal cortex

2.36

1.02

3.70E-02

OGG1

Frontal cortex

2.69

1.02

3.70E-02

Cerebellum

5.18

1.02

2.90E-04 *

Hippocampus

1.85

1.02

5.70E-02

Entorhinal cortex

3.01

1.02

1.30E-01

Polβ

Frontal cortex

1.36

0.78

3.40E-02

Cerebellum

18.69

0.78

4.70E-04 *

Hippocampus

1.36

0.78

2.80E-03

Entorhinal cortex

1.20

0.78

2.30E-02

PARP1

Frontal cortex

1.83

0.87

4.60E-02

Cerebellum

5.31

0.87

1.30E-02

Hippocampus

1.81

0.87

5.50E-03

Entorhinal cortex

2.15

0.87

1.20E-02

  1. Abbreviations: NGE normalized mRNA levels, significant p-values: *