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Fig. 3 | Molecular Brain

Fig. 3

From: Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety

Fig. 3

Behavioral effect of drug treatment in mice submitted to five times repeated EPM test. We compare different sessions in mice treated with a single injection i.p. of: A 1 ) (+) MK-801 (0.25 mg/kg), B 1 ) ifenprodil (10 mg/kg), C 1 ) ifenprodil (20 mg/kg), D 1 ) nimodipine (10 mg/kg), E 1 ) naloxone (5 mg/kg), 30 min before and the same sessions between control and treated mice tested five times in the EPM and retested after 24 h. Black circular symbols and white triangles are means ± SEM (error bars) of control and injected mice per session. In A 1 ) the (**) indicates a significant difference from the first and the second session of the same group. The (#) indicates a significant difference between control and treated mice in the same session. In B 1 ) the (*/**) indicate a significant difference, within the ifenprodil group, between the first and the second session and the others. No significant difference is detected between control and treated mice of the same session. In C 1 ) the (*/**) indicate a significant difference, within ifenprodil group, from the (first/first and second) session of the same group (same symbol). The (#) indicates a significant difference between control and treated mice for the same session. In D 1 ) the (*) indicates a significant difference between the first session and the others within nimodipine group. The (#) indicates a significant difference between control and treated mice of the same session. In E 1 ) the (*) indicates a significant difference, within the naloxone group, from the first session of the same group (same symbol). The (#) indicates a significant difference between control and treated mice in the same session. Number of entries in total arms of control mice and mice treated with a single injection i.p. of: A 2 ) (+) MK-801, B 2 ) ifenprodil, C 2 ) ifenprodil, D 2 ) nimodipine, E 2 ) naloxone, are represented with black and blue bars (means ± SEM). Red and striped bars express respectively the number (means ± SEM) of the entries in the open arms of control mice and treated mice. In A 2 ) the (**) indicates a significant difference of the same parameter compared to first and second session of the same group (same bar color). The (#) indicates a significant difference of the same behavioral parameters between the same sessions of the two groups. In B 2 ) the (*/**/****) on the blue and striped bar indicate a significant difference respectively from the (first/first and second/first, second, third and 24 h) session of the same group (same bar color). The (#) indicates a significant difference from the control group of the behavioral parameters in the same session. In C 2 ) the (*/**/***/****) on the blue and striped bar indicate a significant difference respectively from the (first/first and second/first, second, and 24 h/first, second, third and 24 h) session of the same group (same bar color). The (#) indicates a significant difference of the behavioral parameters from the control group in the same session. In D 2 ) the (*) on the blue and striped bar indicates a significant difference in the entries between the first and the other sessions of the same group (same bar color). The (#) indicates a significant difference from the control group in the behavioral parameters of the same session. In E 2 ) the (*/**/***) on the blue and striped bar indicate a significant difference respectively from the (first/first and second/first, second, third) session of the same group (same bar color). The (#) indicates a significant difference of the behavioral parameters from the control group in the same session

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