Fig. 4
From: Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety
AC8 KO mice, but not AC1 KO, do not display a long-lasting anxiety-like behavior during the repeated EPM test. We compare different sessions in: A 1 ) AC1 KO, B 1 ) AC8 KO mice group and the same sessions between control and KO mice tested five times in the EPM and retested after 24 h. Black circular symbols and white triangles are means ± SEM (error bars) of control and KO mice per session. In A 1 ) the (*) indicates a significant difference, within AC1 KO group (same symbol) from the first session. The (#) indicates a significant difference between control and AC1 KO mice of the same session. In B 1 ) no significant difference is present within AC8 KO group (same symbol) along the entire test. The (#) indicates a difference between control and AC8 KO mice of the same session. Black and blue bars represent the number (means ± SEM) of the total entries of control and A 2 ) AC1 KO mice, B 2 ) AC8 KO mice. Red and striped bars represent respectively the number (means ± SEM) of the entries in the open arms of control and KO mice in the same sessions. In A 2 ) the (*/**/***) on the blue and striped bar indicate a significant difference respectively from the (first/first and second/first, second, third) session of the same group (same bar color). No significant difference of the behavioral parameters from the control group in the same session. In B 2 ) the (*/**) on the blue and striped bar indicate a significant difference respectively from the (first/first and second) session of the same group (same bar color). The (#) indicates a significant difference of the behavioral parameters from the control group in the same session