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Fig. 5 | Molecular Brain

Fig. 5

From: Glycine confers neuroprotection through microRNA-301a/PTEN signaling

Fig. 5

miR-301a mediates glycine-induced neuroprotective effect. a, Glycine treatment increases miR-301a expression after OGD (n = 3, *P < 0.05 vs. Sham, # P < 0.05 vs. Inj, ANOVA test). b, Treatment of miR-301a antagomir, but not antagomir control, attenuates glycine-induced neuroprotection against LDH release in cultured cortical neurons subjected to OGD insult. Left, LDH assay; Right, MTT assay (n = 6, *P < 0.05 vs. Sham, # P < 0.05 vs. Inj, **P < 0.05 vs. Inj + Gly, ANOVA test). c, Treatment of miR-301a agomir in cultured cortical neurons does not enhance glycine-induced neuroprotective effect after OGD insult. Left, LDH assay; Right, MTT assay (n = 6, *P < 0.05 vs. Sham, # P < 0.05 vs. Inj + Gly, ANOVA test). Inj, injury; Gly, glycine; Ant, antagomir; Ant-con, antagomir control; Ago, agomir; Ago-con, agomir control

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