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Table 1 Quantitative data for retinal axonal projections to the suprachiasmatic nucleus (SCN), dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), medial terminal nucleus (MTN) and superior colliculus (SC)

From: Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus

Structure Measurement W4-WT AE1-WT AF2-WT Average SD T1-KO W1-KO AE2-KO AF1-KO Average SD KO vs WT; U-test statistics (2-tailed)
SCN Volume contra proj (mm3) 0.0145 NA 0.0130 0.0138 0.0011 0.0114 0.0169 0.0119 0.0132 0.0134 0.0025 −2.9 %; NS (P = 0.64)
  Volume ipsi proj (mm3) 0.0129 NA 0.0125 0.0127 0.0003 0.0132 0.0119 0.0131 0.0116 0.0125 0.0008 −1.6 %; NS (P = 1)
dLGN A-P length (max; μm) 940 910 1040 963 68 930 1022 1050 1130 1033 83 +7.3 %; NS (P = 0.29)
  Lat extension (μm) 900 780 720 800 92 750 780 720 750 750 24 −6.3 %; NS (P = 0.47)
  Volume contra proj (mm3) 0.1583 0.1284 0.1029 0.1299 0.0277 0.1146 0.1412 0.1389 0.1781 0.1432 0.0262 +10 %; NS (P = 0.48)
  Volume ipsi proj (mm3) 0.0207 0.0126 0.0161 0.0165 0.0041 0.0214 0.0168 0.0211 0.0139 0.0183 0.0036 +11 %; NS (P = 0.29)
  Ratio ipsi/contra 13.08 % 9.81 % 15.65 % 12.85 % 2.92 % 18.67 % 11.90 % 15.19 % 7.80 % 13.39 % 4.64 % +4.2 %; NS (P = 0.16)
vLGN A-P length (max; μm) 815 591 740 715 114 760 662 566 730 680 86 −4.9 %; NS (P = 0.48)
  Lat extension (μm) 450 360 450 420 52 360 450 450 510 443 62 +5.5 %; NS (P = 0.55)
  Volume contra proj (mm3) 0.0398 0.0407 0.0418 0.0408 0.0010 0.0325 0.0353 0.0383 0.0464 0.0381 0.0060 −7 %; NS (P = 0.29)
  Volume ipsi proj (mm3) 0.00699 0.00651 0.00668 0.00673 0.00024 0.00656 0.00496 0.00631 0.00449 0.00558 0.00101 −17 %; NS (P = 0.077)
  Ratio ipsi/contra 17.56 % 16.00 % 15.98 % 16.51 % 0.91 % 20.18 % 14.05 % 16.48 % 9.68 % 15.10 % 4.41 % −8.8 %; NS (P = 0.72)
MTN Volume contra proj (mm3) 0.00912 0.00755 0.00755 0.00807 0.00091 0.0112 0.0105 0.0096 0.00915 0.01011 0.00092 +25.3 %; S ( P= 0.034)
  Volume ipsi proj (mm3) none none none    none none none none    
SC A-P length (max; μm) 2100 1770 1930 1933 165 1765 1815 1680 1550 1703 116 −12 %; NS (P = 0.077)
  Lateral extension (μm) 1500 1530 1590 1540 46 1650 1620 1530 1560 1590 55 +3.2 %; NS (P = 0.21)
  Thickness contra proj (max; μm) 250 255 270 258 10 195 215 210 220 210 11 −19 %; S ( P= 0.032)
  Volume contra proj (mm3) 0.526 0.454 0.504 0.495 0.037 0.315 0.414 0.302 0.321 0.338 0.051 −32 %; S ( P= 0.034)
  Volume ipsi proj (mm3) 0.00654 0.00726 0.00817 0.00732 0.00082 0.00127 0.00104 0.00088 0.00051 0.00093 0.00032 −87 % (~8 fold smaller); S ( P= 0.034)
  Ratio ipsi/contra 1.24 % 1.60 % 1.62 % 1.49 % 0.21 % 0.40 % 0.25 % 0.29 % 0.16 % 0.28 % 0.10 % −81 % (~5.3 fold smaller); S ( P= 0.034)
  1. Abbreviations: ipsi ipsilateral, contra contralateral, proj projections, S significant; NS not significant, KO knockout, WT wild-type. Bold is used to indicate averages and standard deviations, as well as significant data in the last column