Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus

Li, Xiaodong; Gaillard, Frédéric; Monckton, Elizabeth A.; Glubrecht, Darryl D.; Persad, Amit R. L.; Moser, Markus; Sauvé, Yves; Godbout, Roseline

doi:10.1186/s13041-016-0244-0

Molecular Brain

Table 1 Quantitative data for retinal axonal projections to the suprachiasmatic nucleus (SCN), dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), medial terminal nucleus (MTN) and superior colliculus (SC)

From: Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus

Structure	Measurement	W4-WT	AE1-WT	AF2-WT	Average	SD	T1-KO	W1-KO	AE2-KO	AF1-KO	Average	SD	KO vs WT; U-test statistics (2-tailed)
SCN	Volume contra proj (mm³)	0.0145	NA	0.0130	0.0138	0.0011	0.0114	0.0169	0.0119	0.0132	0.0134	0.0025	−2.9 %; NS (P = 0.64)
	Volume ipsi proj (mm³)	0.0129	NA	0.0125	0.0127	0.0003	0.0132	0.0119	0.0131	0.0116	0.0125	0.0008	−1.6 %; NS (P = 1)
dLGN	A-P length (max; μm)	940	910	1040	963	68	930	1022	1050	1130	1033	83	+7.3 %; NS (P = 0.29)
	Lat extension (μm)	900	780	720	800	92	750	780	720	750	750	24	−6.3 %; NS (P = 0.47)
	Volume contra proj (mm³)	0.1583	0.1284	0.1029	0.1299	0.0277	0.1146	0.1412	0.1389	0.1781	0.1432	0.0262	+10 %; NS (P = 0.48)
	Volume ipsi proj (mm³)	0.0207	0.0126	0.0161	0.0165	0.0041	0.0214	0.0168	0.0211	0.0139	0.0183	0.0036	+11 %; NS (P = 0.29)
	Ratio ipsi/contra	13.08 %	9.81 %	15.65 %	12.85 %	2.92 %	18.67 %	11.90 %	15.19 %	7.80 %	13.39 %	4.64 %	+4.2 %; NS (P = 0.16)
vLGN	A-P length (max; μm)	815	591	740	715	114	760	662	566	730	680	86	−4.9 %; NS (P = 0.48)
	Lat extension (μm)	450	360	450	420	52	360	450	450	510	443	62	+5.5 %; NS (P = 0.55)
	Volume contra proj (mm³)	0.0398	0.0407	0.0418	0.0408	0.0010	0.0325	0.0353	0.0383	0.0464	0.0381	0.0060	−7 %; NS (P = 0.29)
	Volume ipsi proj (mm³)	0.00699	0.00651	0.00668	0.00673	0.00024	0.00656	0.00496	0.00631	0.00449	0.00558	0.00101	−17 %; NS (P = 0.077)
	Ratio ipsi/contra	17.56 %	16.00 %	15.98 %	16.51 %	0.91 %	20.18 %	14.05 %	16.48 %	9.68 %	15.10 %	4.41 %	−8.8 %; NS (P = 0.72)
MTN	Volume contra proj (mm³)	0.00912	0.00755	0.00755	0.00807	0.00091	0.0112	0.0105	0.0096	0.00915	0.01011	0.00092	+25.3 %; S ( P = 0.034)
	Volume ipsi proj (mm³)	none	none	none			none	none	none	none
SC	A-P length (max; μm)	2100	1770	1930	1933	165	1765	1815	1680	1550	1703	116	−12 %; NS (P = 0.077)
	Lateral extension (μm)	1500	1530	1590	1540	46	1650	1620	1530	1560	1590	55	+3.2 %; NS (P = 0.21)
	Thickness contra proj (max; μm)	250	255	270	258	10	195	215	210	220	210	11	−19 %; S ( P = 0.032)
	Volume contra proj (mm³)	0.526	0.454	0.504	0.495	0.037	0.315	0.414	0.302	0.321	0.338	0.051	−32 %; S ( P = 0.034)
	Volume ipsi proj (mm³)	0.00654	0.00726	0.00817	0.00732	0.00082	0.00127	0.00104	0.00088	0.00051	0.00093	0.00032	−87 % (~8 fold smaller); S ( P = 0.034)
	Ratio ipsi/contra	1.24 %	1.60 %	1.62 %	1.49 %	0.21 %	0.40 %	0.25 %	0.29 %	0.16 %	0.28 %	0.10 %	−81 % (~5.3 fold smaller); S ( P = 0.034)

Abbreviations: ipsi ipsilateral, contra contralateral, proj projections, S significant; NS not significant, KO knockout, WT wild-type. Bold is used to indicate averages and standard deviations, as well as significant data in the last column

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ISSN: 1756-6606

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