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Fig. 4 | Molecular Brain

Fig. 4

From: Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Fig. 4

Morphology, location and ultrastructure of the ribbon photoreceptor presynaptic terminals in the adult retina differed dramatically between WT, APLP2-KO and APP-KO. a-l Longitudinal cryostat sections of retinas immunostained for (a-c) RIBEYE, (d-f) PNA, (g-i) VGLUT1 and (j-l) PSD-95 from (a, d, g and j) WT, (b, e, h and k) APLP2-KO and (c, f, i and l) APP-KO mice. a-c Arrows indicate cone pedicles. m-t Electron micrographs of longitudinal sections of (m and n) WT, (o-r) APLP2-KO and (s and t) APP-KO. Arrows indicate rod spherules which displayed a densely stained retracting morphology (p) and triads laterally oriented (q), instead of facing the OPL (asterisk). Cone terminal (C), rod terminal (R), synaptic ribbon (SR), Tri (triad), Arciform density (Arc). Scale bars: 15 μm (a-c); 20 μm (d-l); 2 μm (m,o,p,s); 0.5 μm (n,q,r,t)

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Molecular Brain

ISSN: 1756-6606