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Fig. 9 | Molecular Brain

Fig. 9

From: Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Fig. 9

Altered transcription of specific complement pathway and pre- and postsynaptic proteins in APLP2-KO retina. a Schematic indicating the transcriptional alterations occurring in the pre- and postsynaptic gene network in the APLP2-KO retina. OPL synapse impairment was accompanied by specific change in synaptic gene expression showing enrichment (↑) of genes important for presynaptic function/organization ─ RIBEYE, Bassoon, Munc13, Syntaxin1, SNAP25, Synaptogamin-1, Cav1.4, L1CAM, TRPM1, and impoverishment (↓) of postsynaptic genes ─ mGluR6, Gα0 and PKCα. b Relative mRNA expression levels of differentially expressed genes determined by qRT-PCR and the calculated fold change in APLP2-KO retina relative WT. Mean ± s.e.m. N = 10 mice per genotype. *, p < 0.05; **, p < 0.01 vs WT (t-test)

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Molecular Brain

ISSN: 1756-6606