Patient | Gender | Age (years) | Diagnosis | LIS grading [35] | Cerebral cortex | Corpus callosum | Cerebellum | Basal ganglia | Brain stem | Clinical information | Same mutation reported previously |
---|---|---|---|---|---|---|---|---|---|---|---|
A | Male | 0 | Microlissencephaly with cerebellar hypoplasia | Grade 1 | Lissencephaly | Agenesis | Hypoplastic | Hypoplastic | Hypoplastic | Brain stem dysfunction, seizure, and developmental delay. Died at 2Â years old. | Kumar RA et al. [5] |
B | Male | 2 | Lissencephaly | Grade 4 | Agyria-pachygyria (posterior > anterior gradient) | Present, abnormal | Not hypoplastic | Hypoplastic | Not hypoplastic | Intellectual delay and intractable seizures. Word speech at 3 years old. Has survived for 4 years now. | Keays DA et al. [4] |