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Fig. 3 | Molecular Brain

Fig. 3

From: A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway

Fig. 3

Changes in necrotic and apoptotic neurons, and brain water content after A1AR stimulation or inhibition. a FJB staining showing effects of A1AR on SBI at 48 h after ICH onsets. Representative images from sham, ICH, ICH + DMSO, ICH + R-PIA, and ICH + 8-PT groups. Each group was subjected to ICH except for the sham group. Scale bar = 50 μm. b Quantification of the FJB staining in each group. FJB-positive cells were counted per unit area. *p < 0.05 for the ICH group versus the sham group, #p < 0.05 for the ICH + R-PIA group versus the ICH group, & p < 0.05 for the ICH + 8-PT group versus the ICH group. c Brain water content of sham, ICH, ICH + R-PIA, and ICH + 8-PT groups at 48 h after ICH onsets. *p < 0.05 for the ICH group versus the sham group, #p < 0.05 for the ICH + R-PIA group versus the ICH group, & p < 0.05 for the ICH + 8-PT group versus the ICH group. d TUNEL staining to elucidate the role of A1AR in OxyHb-treated neurons in vitro. Representative images from control, OxyHb, OxyHb + DMSO, OxyHb + R-PIA, and OxyHb + 8-PT groups. Each group was subjected to OxyHb except for the control group. Scale bar = 20 μm. e The percentage of TUNEL-positive cells. *p < 0.05 for the OxyHb group versus the control group, #p < 0.05 for the OxyHb + R-PIA group versus the OxyHb group

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Molecular Brain

ISSN: 1756-6606