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Fig. 3 | Molecular Brain

Fig. 3

From: Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

Fig. 3

Changes in polyneuronal innervation of the NMJ after stimulation and inhibition of the mAChR. The figure shows the percentage of singly-, dually- and triply- (or more) innervated NMJs in the untreated YFP control mice (exposed to PBS applications) and after 2 (P7 in a), 4 (P9, in b) and in some cases 10 (P15, in c) applications (one application every day after P5) of the mAChR agonist (ago.) oxotremorine (OXO) and such antagonists (ant.) as atropine (AT), pirenzepine (PIR), methoctramine (MET) and muscarinic toxin 3 (MT3). Fisher’s test: * p < 0,05, ** p < 0,01, *** p < 0,005

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Molecular Brain

ISSN: 1756-6606