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Fig. 2 | Molecular Brain

Fig. 2

From: Acid Sensing Ion Channels (ASICs) in NS20Y cells – potential role in neuronal differentiation

Fig. 2

Inhibition of ASIC current by amiloride and PcTX1 and modulation of ASIC current by zinc and zinc chelator in NS20Y cells. a Amiloride dose dependently inhibits the ASIC current in NS20Y cells with a half-maximal inhibitory concentration (IC50) of 11.04 μM (n = 5). b PcTX1, at 10 nM, also significantly inhibits the ASIC current in NS20Y cells (**p < 0.01, n = 9). c Zinc chelator, TPEN, at 100 μM, significantly potentiates ASIC currents (p < 0.05, n = 7). d Zinc, 100 μM causes a significant inhibition of ASIC currents (p < 0.05, n = 7)

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