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Fig. 5 | Molecular Brain

Fig. 5

From: Acid Sensing Ion Channels (ASICs) in NS20Y cells – potential role in neuronal differentiation

Fig. 5

cpt-cAMP increases ASIC1a expression and ASIC1a current. a ASIC1a protein expression by Western blot. Blots show immunoreactivity to ASIC1 and Beta-actin at their expected molecular weights. After treatment with 1 mM cpt-cAMP, there is an increase in the expression of ASIC1a as evidenced by an increase in density. b Summary data of Western blotting shows that cpt-cAMP significantly increased ASIC1a protein expression (p = 0.05) (n = 12). c Example of whole cell recording that illustrates an increase in ASIC1a current after 72-h treatment with cpt-cAMP. d Summary data showing the ASIC current density in NS20Y cells from different treatment groups. There is a significant increase in the density of peak ASIC current in NS20Y cells treated with cpt-cAMP (* p < 0.05 vs. control, n = 12 in each group)

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