Fig. 1
Fvb/n mice were exposed to contextual fear conditioning. a Illustration of the scheme for the contextual fear conditioning test (b) At day 2, mice displayed increased freezing behavior at 1st and 2nd electric shocks (1/2), the 2nd and 3rd (2/3) and after the 3rd electric shocks (3/E) 1/2, 2/3 and 3/E, (17.43 ± 7.86 %, 32,95 ± 2.88 % and 55.83 ± 5.72 %), respectively, indicating that the mice were well trained by the fear conditioning process. c At day 3, the test group exhibited significantly increased time freezing (71.786 ± 3.84 %, ***p < 0.001), compared to the control group (4.817 ± 0.447 %), indicating that contextual fear memory was induced by our contextual fear conditioning protocol. *p < 0.05 compared to shock 1 (b) or control (c). Data are presented as the mean ± SEM. Cont, control group