Fig. 3

DPAT-induced hypothermia in Deaf1 knockout mice. a, b Early generation (<2) male Deaf1-/- mice show enhanced DPAT-induced hypothermia. Average body temperature change over time for male a or female b Deaf1 wild-type (WT) and Deaf1 knockout (KO) on C57BL/6-BALB/c background following 0.9 % saline or 0.5 mg/kg 8-OH-DPAT (DPAT) injection. *p < 0.05; **p < 0.01; ***p < 0.001 vs. wild-type. c, d Reduced DPAT-induced hypothermia in late generation (≥3) Deaf1-/- male mice. Data are presented as mean ± SE; *p < 0.05; ***p < 0.001 vs. wild-type