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Fig. 2 | Molecular Brain

Fig. 2

From: Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome

Fig. 2

Hippocampal LTP is impaired in CD mice. a Input-output curves at the CA3-CA1 hippocampal synapse. The stimulating electrode was placed in the Schaffer collateral fibers and the recording electrode in the stratum radiatum of the CA1 region. Two-way repeated measures ANOVA revealed no differences between genotypes (p = 0.063). WT: n = 20, CD: n = 21. b Time course of normalized fEPSPs showing the effect of TBS (arrow, time 0) in WT and CD mice. Data are expressed as the percentage of mean fEPSP slopes recorded during the baseline period. Insert shows overlaid representative fEPSP traces taken at the indicated time points. WT: n = 12, CD: n = 13. c The extent of synaptic potentiation 55–60 min after TBS was significantly reduced in CD mice (p = 0.035, unpaired t test) compared to WT mice. WT: n = 12, CD: n = 13. Data are presented as the mean ± SEM. p values are shown with asterisks indicating values that are significantly different. *p < 0.05

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