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Fig. 3 | Molecular Brain

Fig. 3

From: Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome

Fig. 3

Presynaptic function and AMPA receptor-mediated synaptic transmission are not altered in CD mice. a Representative traces of PPF at different interstimulus intervals. b The ratio of PPF was obtained by dividing the amplitude of the second fEPSP by the amplitude of the first fEPSP. Two-way repeated measures ANOVA revealed no differences between genotypes (p = 0.37). WT: n = 19, CD: n = 20. c Normal PTP in CD mice. TBS was given at t = 0 and the fEPSP were recorded immediately after the tetanus. WT: n = 12, CD: n = 14. d Representative traces of miniature mEPSCs from WT and CD neurons. e Cumulative probability analysis of the distribution of inter-event intervals between mEPSCs showed no differences between WT and CD mice (p = 0.341, Kolmogrov-Smirnov test). f Cumulative probability analysis of mEPSCs amplitude showed no differences between WT and CD mice (p = 0.745, Kolmogrov-Smirnov test). WT: n = 22, CD: n = 12. Data are presented as the mean ± SEM

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