Fig. 5

AMPA/NMDA ratio at Schaffer collateral – CA1 synapse. a Representative WT and CD traces of AMPA and NMDA receptor-mediated response recorded in the same cell at -70 and +40 mV, respectively. b The AMPA receptor current amplitude was calculated at the peak at a holding potential of −70 mV and the NMDA receptor current amplitude was measured 40 ms after stimulation artifact at a holding potential of +40 mV. The AMPA/NMDA ratio in CD neurons was not significantly different (p = 0.643, unpaired t test) from WT neurons. WT: n = 13, CD: n = 14. c Weighted mean decay time constant (Tw) of EPSCs recorded at +40 mV was not different (p = 0.455, unpaired t test) between WT and CD neurons. WT: n = 13, CD: n = 12. Data are presented as the mean ± SEM