Fig. 3
From: Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders
Chromatin perturbations cause behavioral impairments. The expression of the chimeric histone H2B-GFP causes dramatic changes in chromatin architecture, including the loss of peripheral heterochromatin, chromocenter declustering and changes in the texture of the nucleoplasm. This is likely due to stearic impediment of highly-packed tertiary chromatin fiber folding in heterochomatin by the protruding GFP tags. Remarkably, Htr1a alleles (red circles) relocated into the aberrant DNA foci, possibly explaining their downregulation and concomitant alterations in serotonin signaling and behavior