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Table 1 Neuropsychiatric conditions associated with disrupted nuclear organization and 3D chromatin architecture

From: Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders

Condition Disruption Reference
Alzheimer’s disease Lamin B invaginations [80]
Behavioral stress PML clustering [28]
Cocaine addiction Sig-1R-mediated MaoB repression [24]
Epilepsy Chromosomal movements [38]
Fragile X–associated tremor/ataxia syndrome Heterochromatin condensation [76]
Huntington’s disease Super-enhancer dysfunction [82]
Neurodegeneration Disrupted CBS and speckles [29, 30]
Seizures PML clustering
Bdnf relocation
[28, 40]
Alpha thalassemia/mental retardation syndrome X ATRX mutation [72]
Bipolar disorder PCDHα enhancer SNP [88]
Cornelia de Lange syndrome NIPRL, SMC1 and SMC3 mutations [70]
Fryns-Lujan syndrome MED12 mutation [69]
ID, microcephaly and growth retardation CTCF mutation [71]
Impulsive-disinhibited personality SIRPB1 intronic deletion [89]
Opitz-Kaveggia syndrome MED12 mutation [69]
Post-traumatic stress disorder/depression FK506 intronic SNP [93, 94]
Restless Legs syndrome MEIS1 enhancer SNP [79]
Rett syndrome MECP2 mutation [73]
Schizophrenia GRIN2B enhancer SNP
Microsatellite repeats in NRG1 intron 1
GAD1 enhancer-promoter dysfunction
[84, 85, 87]
  1. This list is not exhaustive; it only presents those conditions discussed in the text. The rows under “Seizures” refer to conditions caused by mutations in architectural proteins or regulatory elements