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Fig. 4 | Molecular Brain

Fig. 4

From: Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias

Fig. 4

Increased pThr514 CRMP2 correlates with synaptophysin loss in in LBD parietal cortex. a Bar graph of synaptophysin immunoreactivity (mean ± SEM in arbitrary units) and representative immunoblots, with GAPDH as loading control. Scatter plots of pThr514 CRMP2 with synaptophysin immunoreactivities in total homogenate fractions of b LBD (DLB + PDD), c DLB and d PDD parietal cortex, with insets indicating rho and p values. Where a correlation is significant, a best-fit regression line (solid line) is added together with its 95 % prediction intervals (dotted lines). Available N for control (C) = 19; PDD (P) = 19 and DLB (D) = 20. § p < 0.05, significant difference for multiple pair-wise comparisons (one-way ANOVA with Bonferroni post-hoc tests). *p < 0.05, significant Spearman correlations

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Molecular Brain

ISSN: 1756-6606