Table 1 Classification of the tissue histology formed by iPSC-NSPCs in mouse CNS
(A) Histology classification of tissues with maturational patterns. | |||
Differentiation | Neural differentiation | Mesenchymal differentiation | |
Maturation | Maturing/matured | Under-maturation | Maturing/matured |
Histology (Identification on H&E staining) | DNT (either identifiable or non-identifiable) | BLT (identifiable) | Benign mesenchymal tissue (identifiable) |
UDNT (identifiable) | |||
Location | DNT: (1) Parencymal DNT; around central canal or cyst (2)Subpial DNT; beneath the pia matter | BLT:Usually extraparenchymal, but rarely found intraparenchymal | Benign mesenchymal tissue: Extraparenchymal |
UDNT: Extraparenchymal and intraparenchymal | |||
(B) Scattered neural cell classification. | |||
| Â | Migrating neural cells | Subpial neural cells | Â |
Maturation | Immature/maturing (NESTIN+/-) | Immature/maturing (NESTIN+/-) | Â |
Mature (NESTIN-) | Â | ||
Fate | (1) Individual cell maturation | Contribute to subpial DNT formation | Â |
(2) Contribute to DNT formation | Â | ||
(3) Possibly involved in UDNT formation | Â | ||