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Fig. 4 | Molecular Brain

Fig. 4

From: Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines

Fig. 4

Generation of various types of functional neurons from LiPSCs with the dNS method. a Representative images of DF-iPSC- and LiPSC-derived neurons and glial cells stained with antibodies against the indicated markers. Scale bars = 50 μm. bc Ratio of cell types differentiated from DF-iPSCs and LiPSCs (n = 3 independent experiments; means ± SEM; n.s., not significant; Student’s t-test). d Summary of cell types produced from each hiPSC line (n = 3). e Representative images of DF-iPSC- and LiPSC-derived neuronal subtypes stained with antibodies against the indicated markers. Scale bars = 50 μm. fh Ratio of neuronal subtypes differentiated from DF-iPSCs and LiPSCs (n = 3 independent experiments; means ± SEM; n.s., not significant; Student’s t-test). i Summary of neuronal subtypes produced from each hiPSC line (n = 3). j Current-voltage plot of the sodium and potassium currents of neurons derived from LiPSCs (n = 6 independent experiments; means ± SEM). k Voltage-dependent sodium and potassium currents in neurons derived from LiPSCs. l Representative traces of the membrane potential of LiPSC-derived neurons in response to step depolarization by a current injection

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