Fig. 6
From: PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons
Proposed model for PERK’s regulation of Gq protein-coupled Ca2+ dynamics in pyramidal neurons. Upon extracellular ligand binding, Gq protein-coupled receptor is activated, which subsequently activates Gq/PLC. Activated PLC hydrolyzes PIP2 into IP3 and DAG. Increased cytosol IP3 induces ER Ca2+ depletion by binding with ER-resident IP3R, which may activate PERK due to Ca2+ dissociation from its regulatory domain in the ER. Activated PERK may then restore ER Ca2+ level by inhibiting IP3R mediated ER Ca2+ release and activating receptor-operated Ca2+ entry