Fig. 3
From: A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell cultures
ASICs do not mediate substantial fraction of PSCs at hippocampal GABAergic synapses. Top panel: only a small fraction of evoked GABAergic PSCs is bicuculline-resistant. a. An example of original current traces (averages of 10 sequential PSCs) before and after bicuculline (20 μM) application. This is an example of a relatively large residual current. For the experiments described below, we selected cells with relatively large residual currents. b. Summary graph (n = 20). In control (before bicuculline), absolute amplitude of currents (mean ± S.D) was: -336.5 ± 144.7 pA. Bottom panel: 5b does not strongly affect bicuculline-resistant (residual) currents at GABAergic connections. c. Superimposed traces of original current traces (averages of 10 sequential PSCs) before and after 5b (1 μM) application. d. Summary graph (n = 5). In control (before 5b application), absolute amplitude of currents (mean ± S.D) was: -45.8 ± 21.6 pA