Fig. 1From: Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits DISC1 L100P homozygous mutant shows normal behaviors in locomotor activity, anxiety and depression, spatial learning and memory. a In the open field (OF) test, L100P mice (n = 10) and WT mice (n = 11) spent similar time exploring center or peripheral area. b In the elevated plus maze (EPM) test, L100P mice (n = 10) and WT mice (n = 11) spent similar time exploring the open or close arms. c In the forced swim (FS) test, the immobility time of L100P mice (n = 10) and WT mice (n = 11) were similar. d In social interaction (SI) test, L100P mice (n = 10) and WT mice (n = 10) spent similar time interacting with an unfamiliar, ovariectomized C57BL/6 J female mouse. e Time to locate the hidden platform as a function of training days in Morris water maze. f Water maze probe test at day 5 showing that both L100P mice (n = 19) and WT littermates (n = 20) spent significant more time searching in the training quadrant where the platform was located during training than in the other three quadrants. Two-way ANOVA and Bonferroni post-tests, ***P < 0.001. All data are shown as means ± SEM.Back to article page