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Fig. 1 | Molecular Brain

Fig. 1

From: Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits

Fig. 1

DISC1 L100P homozygous mutant shows normal behaviors in locomotor activity, anxiety and depression, spatial learning and memory. a In the open field (OF) test, L100P mice (n = 10) and WT mice (n = 11) spent similar time exploring center or peripheral area. b In the elevated plus maze (EPM) test, L100P mice (n = 10) and WT mice (n = 11) spent similar time exploring the open or close arms. c In the forced swim (FS) test, the immobility time of L100P mice (n = 10) and WT mice (n = 11) were similar. d In social interaction (SI) test, L100P mice (n = 10) and WT mice (n = 10) spent similar time interacting with an unfamiliar, ovariectomized C57BL/6 J female mouse. e Time to locate the hidden platform as a function of training days in Morris water maze. f Water maze probe test at day 5 showing that both L100P mice (n = 19) and WT littermates (n = 20) spent significant more time searching in the training quadrant where the platform was located during training than in the other three quadrants. Two-way ANOVA and Bonferroni post-tests, ***P < 0.001. All data are shown as means ± SEM.

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