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Fig. 5 | Molecular Brain

Fig. 5

From: Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling

Fig. 5

Structural models of the Na+/K+-ATPase catalytic site in (a) E1P and (b) E2P conformations (PDB ID 4HQJ and 2ZXE respectively). In both a and b, color-codingshows in blue: the amino-terminal; red: carboxyl-terminal, blue and cyan: A domain; yellow: P domain; green: N domain. Deamidated residues N210, D220 and N715 are highlighted in red. Magnesium ions are represented in magenta. (Adapted from Adav et al. [45]). c Structural model of deamidation sitesin protein S100A9 (RCSB Protein Data Bank accession code: 1XK4). The EF hand calcium binding motifs are shown in yellow and deamidation sites are highlighted in magenta and blue. d EF hands and deamidation sites (adapted from Adav et al. [53])

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