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Fig. 3 | Molecular Brain

Fig. 3

From: Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing

Fig. 3

Heantos inhibits burst firing in VB thalamic neurons. a Representative voltage traces showing input-output response of the same VB thalamic neuron before (left) and after (right) application of Heantos (1 mg/ml). Lower panels show current injection protocol. Black traces show the threshold burst voltage and corresponding current injection. The same voltage traces are displayed at a higher time resolution of the region delineated by grey box for clarity. b Histograms summarizing mean burst threshold and c resting membrane potential before and after Heantos (1 mg/ml) or control (aCSF). d Histograms summarizing mean number of action potentials per burst and e input resistance for VB thalamic neurons before and after a 5 min application of aCSF (n = 5) or Heantos (1 mg/ml (n = 5))

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Molecular Brain

ISSN: 1756-6606