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Fig. 6 | Molecular Brain

Fig. 6

From: Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

Fig. 6

Decreased WAY-161503 induced activation of ARC POMC neurons in PWS-IC mice. Dual immunofluorescence histochemical colocalisation of cFOS (nuclear, green) and POMC (cytoplasmic, red) in the brains of (a, c) vehicle and (B, D) WAY-161503 treated (a, c) WT and (b, d) PWS-IC mice. Inserts in (c, d) represent high magnification images of colocalisation. WAY-161503 administration failed to activate ARC POMC neurons in PWS-IC mice. VMH, ventromedial nucleus of the hypothalamus; 3 V, third ventricle. Scale bar (a), 100 μm and relates to (ad). Scale bar (C’), 25 μm and relates to (C’ and D’)

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