Fig. 7
From: Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
OXT administration improved social memory of ION mice. The three chamber test was conducted 20 min after OXT or saline administration. Intact sociability indicated by preference for a stranger mouse vs an inanimate ball (a) and social novelty revealed by preference for a novel stranger vs a familiar stranger (b) in ION-transected mice are not altered by nasal OXT administration. However, the social memory deficit in ION-transected mice shown by a similar investigation time to stranger 3 (p = 0.637) is largely restored by nasal OXT administration as shown by the appearance of spending more time with stranger 3 (c). Data were analyzed by repeated-measures ANOVA and results are expressed as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 via Fisher’s PLSD post hoc tests. n = 8 (1:1 sex ratio) per group