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Table 4 ASIC expression in the nervous system

From: Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat

 

DRG

SP

CO

HC

OL

CE

BS

Whole brain

ASIC1

NB (r[28])

NB (r[28])

ISH (m[27], r[58]) NB (r[28])

IHC (m[7])

ISH (m[27, 25], r[58]) IHC (m[7])

NB (r[28], h[25])

ISH (m[27, 25], r[58]), IHC (m[7])

ISH (m[27, 25], IHC (m[7]),

NB (r[28])

NB (r[28])

NB (r[28]), ISH (m[25])

ASIC1a

qPCR (h[31, 54], m[14, 54], nmr[14])

qPCR (h[31], m[33]

     

qPCR (h[31, 54], m[54])

ASIC1b

qPCR (m[14, 54], nmr[14])

      

qPCR (m[54])

ASIC2

NB (r[36])

NB (r[36])

ISH (r[26, 36, 58])

ISH (m[25], r[26, 36, 58]) NB (h[25])

EP (m[11])

ISH (m[25], r[26, 36, 58])

ISH (m[25], r[26, 36]

NB (r[36])

NB (r[36])

NB (r[36]) ISH (m[25])

ASIC2a

qPCR (m[14], nmr[14])

qPCR (m[33])

     

qPCR (h[31])

ASIC2b

qPCR (m[14], nmr[14])

qPCR (m[33])

     

qPCR (h[31])

ASIC3

RT (r[35]), NB (r[36]), qPCR (h[31], r[31], m[14], nmr[14])

WB (r[35])

qPCR (h[31], m[33])

RT (r[35]), WB (r[35])

RT (r[35]),

WB (r[35])

 

ISH (r[58])

 

qPCR (h[31]),

ASIC4

 

NB (r[36])

ISH (r[36])

ISH (r[36])

RT (r[37])

ISH (r[36])

 

NB (r[36])

RT (r[37])

NB (r[36]) RT (r[37])

NB (r[36, 37])

  1. Different techniques have been previously used to determine ASIC expression in the nervous system tissues used in this study. Abbreviations used in Table 4 are as follows BS brain stem, CE cerebellum, CO cortex, DRG dorsal root ganglia, EP electrophysiology, HC hippocampus, IHC immunohistochemistry, ISH in situ hybridisation, NB Northern blot, OL olfactory bulb, qPCR quantitative real-time PCR, RT reverse-transcriptase PCR, WB western blot. Species: r rat, h human, m mouse, nmr naked mole rat. Studies listed for ASIC1 and ASIC2 did not differentiate between splice isoforms
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Molecular Brain

ISSN: 1756-6606