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Fig. 2 | Molecular Brain

Fig. 2

From: Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging

Fig. 2

Principal component analysis (PCA) and partial results of the gene ontology (GO)-based microarray analysis. a PCA of hippocampal gene expression profiles. PCA plots show the 2 principle components with the greatest variation, which cover 23% (PC1) and 10% (PC2) (upper panel), or 23% (PC1) and 7.5% (PC3) (bottom panel) of the total variance, respectively. Symbols indicate the PCA representing profiles of control and experimental animals, consisting of 3 independent GeneChip experiments. b Screeplots of PCA results. c Portions of the complete heatmap (Additional file 1: Figure S1) generated by GO-based microarray analysis. The parts with green rectangles in Additional file 1: Figure S1 are extracted and displayed. GO terms are given on the vertical axis, and samples (comparisons of experimental conditions with their controls) are given on the horizontal axis. A dendrogram regarding the samples is shown at the bottom. In particular, our experimental data (GSE62385) are indicated with red-colored letters. P values were calculated by the hypergeometric test and denoted by -log10 P; overrepresented GO terms are shown in red and blue (increased (+) and decreased (−), respectively). Abbreviations: Ctrl = control group, IH5D = exposed to IHT for 5 days, IH5DR2 = exposed to IHT for 5 days, followed by normoxia treatment for 2 days, Ctrl28 = reared at our institution for 28 days, IH28D = exposed to IHT for 28 days, 12 m = reared at our institution for 12 months

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