Fig. 3

Effects of IH5D and IH5DR2 on tau phosphorylation and its related enzymes. a Total tau was not altered between the Ctrl, IH5D, and IH5DR2 groups. Representative blot for total tau or α-tubulin are shown (left panels), as well as quantification (right panels). b Intermittent hypoxia treatment (IHT) produced an increase in tau phosphorylation. Representative blots are shown for each epitope (left panels) and quantification data (right panels). All blots indicated phosphorylated tau. Arrowheads indicated quantified bands. Quantification data include the mean + SEM (n = 9). * p <0.05, ** p <0.01 vs. Ctrl. c Analyses were performed for enzymes (GSK-3β, PP2A, and p70S6K) related to tau phosphorylation. Representative blots (left panels) and quantification data (right panels) are shown. Quantification data include the mean + SEM (n = 5, 6). ** p <0.01 vs. Ctrl