Fig. 1
From: Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease
Methylation of SNCA-intron1 does not differ between PD and controls. SNCA contains 6 exons. A 444 bp region in the intron1 (-483 to -926 bp with respect to ATG) was investigated. The sequence of the studied region is shown and the 23 CpGs are marked by numbers. The priming regions are underlined (a). Relative level of methylation (b) and unmethylated CpG (c) between control (CTRL) and PD groups are shown. No significant difference was observed between two groups for mean methylation level. Analysis of individual CpG site was done from control (n = 8) and PD (n = 8) subjects (d). Analysis did not reveal any significant difference between the groups. For every subject, 9 to 10 clones were studied to get the mean methylation percentage. The data is represented as mean ± SEM. Pair-wise comparison was made by Mann-Whitney t-test to analyze the significance. n.s. represents non-significant difference