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Table 1 Characteristics of iPSC clones

From: Proteasome impairment in neural cells derived from HMSN-P patient iPSCs

  control1 control2 control3 HMSN-P1 HMSN-P2 HMSN-P3
Clone name at establishment TIG107 HC2EL5 hc3NORA ALS43EL1 ALS44E1 ALS44E9
Control or HMSN-P control control control HMSN-P HMSN-P
Gender female male female male female
Age at biopsy 81 64 65 48 52
Disease duration N.A. N.A. N.A. 5 years 12 years
Proximal muscle weakness N.A. N.A. N.A. + +
Bulbar symptoms N.A. N.A. N.A. - -
Respiratory failure N.A. N.A. N.A. - -
Sensory disturbance N.A. N.A. N.A. + +
Genotype N.A. N.A. N.A. TFG (P285L) TFG (P285L)
Origin HDFs PBMCs PBMCs HDFs HDFs
Reprogramming retrovirus episomal episomal episomal episomal
  1. HMSN-P hereditary motor and sensory neuropathy with proximal dominant involvement, HDFs human dermal fibroblasts, PBMCs peripheral blood mononuclear cells, iPSC induced pluripotent stem cell, N.A. not applicable