Fig. 1
From: TBK1: a new player in ALS linking autophagy and neuroinflammation
a Primary structure of TBK1. TBK1 is 729 amino acids in length and comprises four main domains: a kinase domain (KD), ubiquitin-like domain (ULD) and two coiled-coil domains (CCD1 and CCD2). Locations of TBK1 mutations associated with ALS and ALS-FTD are indicated by vertical lines: Black – frame shift mutations, orange – nonsense mutations, green – Missense mutations, blue – in-frame deletions, purple – splice mutations and yellow - insertion mutations. b Tertiary structure of TBK1. The region highlighted in red represents the kinase domain, the turquoise region represents the ubiquitin-like domain and the yellow region represents coiled-coil domain 1. Coiled-coil domain 2 is not shown in this model. Diagram produced in PyMOL using crystal structure data published by Larabi et al. 2013 [40] accessed via protein databank (accession number: 4IWO). (RCSB Protein Data Bank, 2016)