Table 1 Breakdown of TBK1 mutations by disease type and protein domains
From: TBK1: a new player in ALS linking autophagy and neuroinflammation
| Â | Domain | |||
|---|---|---|---|---|
Disease | Kinase domain | Ubiquitin-like domain | CCD1 | CCD2 |
ALS | 32 (84%) | 11 (100%) | 29 (71%) | 2 (25%) |
ALS-FTD | 2 (5%) | 0 (0%) | 9 (22%) | 4 (50%) |
FTD | 4 (11%) | 0 (0%) | 3 (7%) | 2 (25%) |
Total no. cases | 38 | 11 | 41 | 8 |