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Table 1 Breakdown of TBK1 mutations by disease type and protein domains

From: TBK1: a new player in ALS linking autophagy and neuroinflammation

  Domain
Disease Kinase domain Ubiquitin-like domain CCD1 CCD2
ALS 32 (84%) 11 (100%) 29 (71%) 2 (25%)
ALS-FTD 2 (5%) 0 (0%) 9 (22%) 4 (50%)
FTD 4 (11%) 0 (0%) 3 (7%) 2 (25%)
Total no. cases 38 11 41 8